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Article

VCP gene analyses in Japanese patients with sporadic amyotrophic lateral sclerosis identify a new mutation.

Neurobiology of aging - 1 Mar 2015

Hirano Makito, Nakamura Yusaku, Saigoh Kazumasa, Sakamoto Hikaru, Ueno Shuichi, Isono Chiharu, Mitsui Yoshiyuki, Kusunoki Susumu

Abstract excerpt

Accumulating evidence has proven that mutations in the VCP gene encoding valosin-containing protein (VCP) cause inclusion body myopathy with Paget disease of the bone and frontotemporal dementia. This gene was later found to be causative for amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, occurring typically in elderly persons. We thus sequenced the VCP gene in 75 Japanese patients with...

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Source

Identifiers

PMID: 25457024
DOI: 10.1016/j.neurobiolaging.2014.10.012

Genes

VCP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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