Article
Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis.
Neurobiology of aging - 1 Mar 2012
Tiloca Cinzia, Ratti Antonia, Pensato Viviana, Castucci Alessia, Sorarù Gianni, Del Bo Roberto, Corrado Lucia, Cereda Cristina, D'Ascenzo Carla, Comi Giacomo P, Mazzini Letizia, Castellotti Barbara, Ticozzi Nicola, Gellera Cinzia, Silani Vincenzo
Abstract excerpt
Mutations in valosin-containing protein (VCP) gene, already known to be associated with the multisystemic disorder, inclusion body myopathy with Paget's disease and frontotemporal dementia (IBMPFD), have been recently found also in familial cases of amyotrophic lateral sclerosis (ALS). To further define the frequency of VCP mutations in ALS Italian population, we screened a cohort of 166 familial ALS and 14...
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