Article
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Acta neuropathologica communications - 10 Dec 2014
Ayaki Takashi, Ito Hidefumi, Fukushima Hiroko, Inoue Takeshi, Kondo Takayuki, Ikemoto Akito, Asano Takeshi, Shodai Akemi, Fujita Takuji, Fukui Satoshi, Morino Hiroyuki, Nakano Satoshi, Kusaka Hirofumi, Yamashita Hirofumi, Ihara Masafumi, Matsumoto Riki, Kawamata Jun, Urushitani Makoto, Kawakami Hideshi, Takahashi Ryosuke
Abstract excerpt
BACKGROUND: Mutations in the valosin-containing protein (VCP) gene were first found to cause inclusion- body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD). Mutations in the VCP gene were later reported to occur in familial amyotrophic lateral sclerosis (ALS). But the role of VCP in the neurodegenerative processes that occur in ALS remains unknown. The purpose of the present study...
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