Article
Estimating effective population size or mutation rate using the frequencies of mutations of various classes in a sample of DNA sequences.
Genetics - 1 Dec 1994
Fu Y X
Abstract excerpt
Mutations resulting in segregating sites of a sample of DNA sequences can be classified by size and type and the frequencies of mutations of different sizes and types can be inferred from the sample. A framework for estimating the essential parameter theta = 4Nu utilizing the frequencies of mutations of various sizes and types is developed in this paper, where N is the effective size of a population and mu is...
Topics
- Base Sequence
- Computer Simulation
- DNA
- Genetic Variation
- Models, Genetic
- Monte Carlo Method
- Mutation
- Polymorphism, Genetic
- Population Density
- Recombination, Genetic