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Article

Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.

Biochemical and biophysical research communications - 21 Nov 2014

Takeda Koh, Qin Sheng-Ying, Matsumoto Naoki, Yamamoto Kazuo

Abstract excerpt

We previously demonstrated that malectin associates with ribophorin I, which is a subunit of oligosaccharyltransferase in the endoplasmic reticulum (ER). When malectin and ribophorin I are overexpressed in the ER, secretion of an α1-antitrypsin (AT) variant whose folding is defective, termed null Hong Kong (AT(NHK)), is decreased. To confirm whether the interaction between malectin and ribophorin I is involved in...

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PMID: 25451265
DOI: 10.1016/j.bbrc.2014.10.102

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