Article
Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Feb 2015
Church Rachel J, Gatti Daniel M, Urban Thomas J, Long Nanye, Yang Xi, Shi Qiang, Eaddy J Scott, Mosedale Merrie, Ballard Shawn, Churchill Gary A, Navarro Victor, Watkins Paul B, Threadgill David W, Harrill Alison H
Abstract excerpt
Consumer use of herbal and dietary supplements has recently grown in the United States and, with increased use, reports of rare adverse reactions have emerged. One such supplement is green tea extract, containing the polyphenol epigallocatechin gallate (EGCG), which has been shown to be hepatotoxic at high doses in animal models. The Drug-Induced Liver Injury Network has identified multiple patients who have...
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