Article
Interferon lambda-3 is not associated with clinical outcome in patients with HCV-induced compensated cirrhosis: a long-term cohort study.
Antiviral research - 1 Jan 2015
Bruno Savino, Thompson Alex J, Critelli Rosina, Crosignani Andrea, Rossi Sonia, De Lisi Stefania, Cariani Elisabetta, Zermiani Paola, Vaira Valentina, Boccaccio Vincenzo, Maisonneuve Patrick, Villa Erica
Abstract excerpt
BACKGROUND: Interferon Lambda-3 (IFN-λ3) gene polymorphism is associated with spontaneous clearance of hepatitis C virus (HCV) and response to IFN-based therapy (IFN). However, very few data are available about its value in predicting sustained virologic response (SVR) in patients with cirrhosis, and whether IFN-λ3 genotype influences liver disease progression remains unclear. METHODS: We determined IFN-λ3...
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