Article
Family-based association study of common variants, rare mutation study and epistatic interaction detection in HDAC genes in schizophrenia.
Schizophrenia research - 1 Dec 2014
Kebir Oussama, Chaumette Boris, Fatjó-Vilas Mar, Ambalavanan Amirthagowri, Ramoz Nicolas, Xiong Lan, Mouaffak Fayçal, Millet Bruno, Jaafari Nematollah, DeLisi Lynn E, Levinson Douglas, Joober Ridha, Fañanás Lourdes, Rouleau Guy, Dubertret Caroline, Krebs Marie-Odile
Abstract excerpt
BACKGROUND: Histone deacetylases (HDACs) are key enzymes of histone acetylation, and abnormalities in histone modifications and in the level of HDAC proteins have been reported in schizophrenia. The objective of the present study was to systematically test the HDAC genes for its association with schizophrenia. METHODS: A family-based genetic association study (951 Caucasian subjects in 313 nuclear families) using...
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