Autophagy meets fused in sarcoma-positive stress granules.

Abstract excerpt

Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). Mutant FUS selectively accumulates into discrete cytosolic structures known as stress granules under various stress conditions. In addition, mutant FUS expression can alter the dynamics and morphology of stress granules. Although the link between mutant FUS and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy
• Share to Amyotrophic Lateral Sclerosis
• Share to Cytoplasmic Granules