Article
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.
American journal of human genetics - 6 Nov 2014
Gusev Alexander, Lee S Hong, Trynka Gosia, Finucane Hilary, Vilhjálmsson Bjarni J, Xu Han, Zang Chongzhi, Ripke Stephan, Bulik-Sullivan Brendan, Stahl Eli, Kähler Anna K, Hultman Christina M, Purcell Shaun M, McCarroll Steven A, Daly Mark, Pasaniuc Bogdan, Sullivan Patrick F, Neale Benjamin M, Wray Naomi R, Raychaudhuri Soumya, Price Alkes L
Abstract excerpt
Regulatory and coding variants are known to be enriched with associations identified by genome-wide association studies (GWASs) of complex disease, but their contributions to trait heritability are currently unknown. We applied variance-component methods to imputed genotype data for 11 common dis...
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