Sequential feedback induction stabilizes the phosphate starvation response in budding yeast.

doi:10.1016/j.celrep.2014.10.002

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Article

Sequential feedback induction stabilizes the phosphate starvation response in budding yeast.

Cell reports - 6 Nov 2014

Vardi Noam, Levy Sagi, Gurvich Yonat, Polacheck Tamar, Carmi Miri, Jaitin Diego, Amit Ido, Barkai Naama

Abstract excerpt

Depletion of essential nutrients triggers regulatory programs that prolong cell growth and survival. Starvation-induced processes increase nutrient transport, mobilize nutrient storage, and recycle nutrients between cellular components. This leads to an effective increase in intracellular nutrients, which may act as a negative feedback that downregulates the starvation program. To examine how cells overcome this...

Topics

DNA-Binding Proteins
Down-Regulation
Feedback, Physiological
Gene Expression Regulation, Fungal
Genes, Fungal
Mutation
Phenotype
Phosphates
Regulon
Saccharomyces cerevisiae Proteins
Saccharomycetales
Stress, Physiological
Time Factors
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 25437565
DOI: 10.1016/j.celrep.2014.10.002

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