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Article

Topiramate's reduction of body mass index in heavy drinkers: lack of moderation by a GRIK1 polymorphism.

Experimental and clinical psychopharmacology - 1 Oct 2014

Kranzler Henry R, Feinn Richard, Gelernter Joel, Pond Timothy, Covault Jonathan

Abstract excerpt

Topiramate, which interacts with multiple neurotransmitter and enzyme systems, is approved by the Food and Drug Administration to treat seizure disorder, prevent migraine, and (in combination with phentermine) reduce weight. Topiramate has also been shown in multiple studies to reduce heavy drink...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24978347
DOI: 10.1037/a0037309
PMCID: PMC4180772

Genes

GRIK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24978347-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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