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Article

The positive is inside the negative: HER2-negative tumors can express the HER2 intracellular domain and present a HER2-positive phenotype.

Cancer letters - 1 Feb 2015

Panis Carolina, Pizzatti Luciana, Corrêa Stephany, Binato Renata, Lemos Gabriela Ferreira, da Silva do Amaral Herrera Ana Cristina, Seixas Teresa Fernandes, Cecchini Rubens, Abdelhay Eliana

Abstract excerpt

Overexpression of human epithelial growth factor receptor 2 (HER2) is a poor prognostic factor in breast cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity. Receptor dimerization triggers pivotal effector pathways in cancer, such as phosphatidylinositol 3-kinase (PI3K) signaling....

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Identifiers

PMID: 25434795
DOI: 10.1016/j.canlet.2014.11.029

Genes

ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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