Article
Association of ADAMTS12 polymorphisms with rheumatoid arthritis.
Molecular medicine reports - 1 Jul 2012
Nah Seong-Su, Lee Soojeong, Joo Jaesoon, Kim Hyung-Kee, Sohn Dong-Ryul, Kwon Jun-Tack, Woo Kee-Min, Hong Seung-Jae, Kim Hak-Jae
Abstract excerpt
a disintegrin and metalloproteinase (ADAM) with thrombospondin type 1 motif 12 (ADAMTS12) is a degradative enzyme that interacts with the degradable fragments of cartilage oligomeric matrix protein, which is a prominent non-collagenous matrix component in articular cartilage. ADAMTS12 has been observed in the cartilage, synovial fluid and serum of arthritic patients, and may play an important role in the...
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