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Article

Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis.

Frontiers in immunology - 1 Jan 2021

Cai Yujie, Liang Renge, Xiao Shibai, Huang Qin, Zhu Dingji, Shi Guo-Ping, Ouyang Qingqing, Yang Min

Abstract excerpt

Dysregulation of circular RNAs (circRNAs) is involved in various human diseases. Fibroblast-like synoviocytes (FLSs), which form the lining of the joint, are epigenetically imprinted with an aggressive phenotype and contribute to joint destruction in rheumatoid arthritis (RA). In the present study, we identified a novel circRNA, Circ_0088194, which was upregulated in RA fibroblast-like synoviocytes (RA-FLSs) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33692802
DOI: 10.3389/fimmu.2021.628654
PMCID: PMC7937802

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