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Article

Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2007

Drakos Elias, Thomaides Athanasios, Medeiros L Jeffrey, Li Jiang, Leventaki Vasiliki, Konopleva Marina, Andreeff Michael, Rassidakis George Z

Abstract excerpt

PURPOSE: p53 is frequently expressed but rarely mutated in Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin's lymphoma (HL). p53 protein levels are regulated by murine double minute 2 (MDM2) through a well-established autoregulatory feedback loop. In this study, we investigated the effects of nutlin-3A, a recently developed small molecule that antagonizes MDM2 and disrupts the p53-MDM2 interaction, on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17545546
DOI: 10.1158/1078-0432.CCR-06-2581

Genes

MDM2

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Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma.PMID 17545546Read ↗

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