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Article

Heterologous expression of mutated HLA-G1 reduces alloreactivity of human dermal fibroblasts.

Regenerative medicine - 1 Jan 2014

Teklemariam Takele, Zhao Longmei, Hantash Basil M

Abstract excerpt

AIM: To engineer a stable HLA-G molecule and evaluate its immunomodulatory properties in transgenic human dermal fibroblasts (HDFs). MATERIALS & METHODS: A mutated HLA-G1 (mHLA-G1) molecule was generated by modifying the endoplasmic reticulum retrieval motif and 3'-untranslated region miRNA-binding sites of HLA-G1. Immunomodulatory properties of transgenic HDF-mHLA-G1 were evaluated in vitro. RESULTS: Stable...

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Identifiers

PMID: 25431913
DOI: 10.2217/rme.14.58

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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