Article
Association of Toll-like receptor 7 and 8 gene polymorphisms with Graves' disease in Chinese Cantonese population.
Tissue antigens - 1 Jan 2015
Xiao WenJuan, Liu ZeLin, Lin JiangHai, Li JingBo, Wu KeJing, Ma Yun, Xiong ChunJiang, Gong YingXue, Liu ZeHuan
Abstract excerpt
Graves' disease (GD) is a common polygenic multifactorial autoimmune disease. Toll-like receptors (TLRs) play critical roles in the activation of innate and adaptive immune responses. This study investigated the association of TLR7 and TLR8 gene polymorphisms with susceptibility of GD. Five single nucleotide polymorphisms (SNPs), namely, rs179019, rs179010 and rs3853839 in TLR7 and rs3764880 and rs5744088 in...