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Article

Dynamic nature of Staphylococcus aureus type I signal peptidases.

Biophysical journal - 19 Aug 2025

Madsen Jesper J, Yu Wenqi

Abstract excerpt

Molecular dynamics simulations are used to interrogate the dynamic nature of Staphylococcus aureus type I signal peptidases, SpsA and SpsB, including the impact of the P29S mutation of SpsB. Fluctuations and plasticity-rigidity characteristics vary among the proteins, particularly in the extracellular domain. Intriguingly, the P29S mutation, which influences susceptibility to arylomycin antibiotics, affects the...

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Identifiers

PMID: 41404790
DOI: 10.1016/j.bpj.2025.07.008
PMCID: PMC12414704

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