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Article

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a<i>Drosophila</i>Model of Amyotrophic Lateral Sclerosis

26 Nov 2014

Abstract excerpt

TDP-43 is an RNA-binding protein linked to amyotrophic lateral sclerosis (ALS) that is known to regulate the splicing, transport, and storage of specific mRNAs into stress granules. Although TDP-43 has been shown to interact with translation factors, its role in protein synthesis remains unclear, and no in vivo translation targets have been reported to date. Here we provide evidence that TDP-43 associates with...

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PMID: 25429138
DOI: 10.1523/jneurosci.2526-14.2014

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Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a<i>Drosophila</i>Model of Amyotrophic Lateral SclerosisPMID 25429138Read ↗

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