Article
SNP rs11931074 of the SNCA gene may not be associated with multiple system atrophy in Chinese population.
The International journal of neuroscience - 1 Jan 2015
Sun ZhanFang, Xiang XiaoShuang, Tang BeiSha, Chen Zhao, Peng HuiRong, Xia Kun, Jiang Hong
Abstract excerpt
BACKGROUND: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by poorly levodopa-responsive parkinsonism, cerebellar ataxia, and autonomic dysfunction. Pathogenic mechanisms remain obscure, but the neuropathological hallmark is the presence of α-synuclein-positive glial cytoplasmic inclusions. Previous studies suggested that a single nucleotide polymorphism (SNP), rs11931074,...
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