An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson's disease.

doi:10.1007/s10072-018-3538-4

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An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Dec 2018

Liu Xu, Zhu Ruixia, Xiao Tongling, Li Qu, Zhu Ying, He Zhiyi

Abstract excerpt

Large-scale genome-wide association study (GWAS) has identified that the alpha-synuclein (SNCA) rs11931074 polymorphism is associated with Parkinson's disease (PD) susceptibility in individuals of Japanese descent. Subsequently, a number of replication studies have been performed in Asian and Caucasian populations. However, the results remain controversial due to the relatively small sample sizes and genetic...

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PMID: 30120622
DOI: 10.1007/s10072-018-3538-4

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