Article

MiR-34c Downregulation Leads to SOX4 Overexpression and Cisplatin Resistance in Nasopharyngeal Carcinoma

2020-04-22

Abstract excerpt

<title>Abstract</title> <p>Background : A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key component of this signature, miR-34c, revealed its role in chemothe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b37e61b7-d054-5452-a31c-c8ed9222b252
DOI: 10.21203/rs.2.14313/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MiR-34c Downregulation Leads to SOX4 Overexpression and Cisplatin Resistance in Nasopharyngeal CarcinomaDOI 10.21203/rs.2.14313/v2Read

HOTAIR Promotes Cisplatin Resistance of Nasopharyngeal Carcinoma Cells by Regulating Cell Proliferation, Invasion, and Apoptosis via miR-106a-5p/SOX4 AxisSemantic proximity Read

WITHDRAWN: The SOX4–PTBP2 Axis Promotes Proliferation, Invasion and Lymphatic Metastasis in Laryngeal Squamous Cell CarcinomaSemantic proximity Read

A novel miR-200c/c-myc negative regulatory feedback loop is essential to the EMT process, CSC biology and drug sensitivity in nasopharyngeal cancerSemantic proximity Read

Down-regulation of tumor suppressor miR-34a contributes to head and neck cancer by up-regulating MET oncogene and modulating tumor immune evasionSemantic proximity Read

BCAP29/31 as a Poor Prognostic Biomarker for Head and Neck Squamous Carcinoma: Impacting the TGFβ1/Smad- EMT PathwaySemantic proximity Read

Overexpression of SOX4 indicates poor prognosis and promotes progression of hypopharyngeal carcinomaSemantic proximity Read

MicroRNA‐34a: A Key Regulator in the Hallmarks of Renal Cell CarcinomaSemantic proximity Read

Epithelial–mesenchymal transition and cancer stem cells: A route to acquired cisplatin resistance through epigenetics in HNSCCSemantic proximity Read

The impact of<i>ERP29</i>on the progression of pharyngeal squamous cell carcinomaSemantic proximity Read

MiR-29c Inhibits The Metastasis of Oral Squamous Cell Carcinoma And Promotes Its Cell Cycle Arrest By Targeting SERPINH1Semantic proximity Read

Hippo pathway contributes to cisplatin resistant-induced EMT in nasopharyngeal carcinoma cellsSemantic proximity Read

CD44 exerts a functional role during EMT induction in cisplatin-resistant head and neck cancer cellsSemantic proximity Read