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Article

Transcription factor SOX‐5 enhances nasopharyngeal carcinoma progression by down‐regulating <i>SPARC</i> gene expression

17 Dec 2007

Abstract excerpt

Nasopharyngeal carcinoma (NPC) is prevalent in south-eastern Asia, and its tumourigenesis is rather complex. The purpose of this research was to identify the pivotal genes that may be altered during the early stage of NPC progression. Eleven genes were selected by comparative microarray analysis of NPC versus normal nasomucosal cells. The expression of SPARC (secreted protein, acidic, cysteine-rich) was...

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PMID: 18085523
DOI: 10.1002/path.2299

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