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Article

Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis.

The Journal of biological chemistry - 25 Jun 1991

Graham-Lorence S, Khalil M W, Lorence M C, Mendelson C R, Simpson E R

Abstract excerpt

The conversion of androgens to estrogens is catalyzed by an enzyme complex named aromatase, which consists of a form of cytochrome P-450, aromatase cytochrome P-450 (cytochrome P-450AROM), and the flavoprotein, NADPH-cytochrome P-450 reductase. As a first step toward investigation of the structure-function relationships of cytochrome P-450AROM, we have used computer modeling to align the amino acid sequence of...

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PMID: 2050688

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