Article
Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis.
The Journal of biological chemistry - 25 Jun 1991
Graham-Lorence S, Khalil M W, Lorence M C, Mendelson C R, Simpson E R
Abstract excerpt
The conversion of androgens to estrogens is catalyzed by an enzyme complex named aromatase, which consists of a form of cytochrome P-450, aromatase cytochrome P-450 (cytochrome P-450AROM), and the flavoprotein, NADPH-cytochrome P-450 reductase. As a first step toward investigation of the structur...
Topics
- Amino Acid Sequence
- Aromatase
- Catalysis
- Cell Line
- Chromatography, High Pressure Liquid
- Computer Simulation
- Humans
- Kinetics
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Pseudomonas
- Sequence Alignment
- Structure-Activity Relationship
- Substrate Specificity