Article
Heritability of liver enzyme levels estimated from genome-wide SNP data.
European journal of human genetics : EJHG - 1 Sept 2015
van Beek Jenny H D A, Lubke Gitta H, de Moor Marleen H M, Willemsen Gonneke, de Geus Eco J C, Hottenga Jouke Jan, Walters Raymond K, Smit Jan H, Penninx Brenda W J H, Boomsma Dorret I
Abstract excerpt
Variation in the liver enzyme levels in humans is moderately heritable, as indicated by twin-family studies. At present, genome-wide association studies have traced <2% of the variance back to genome-wide significant single-nucleotide polymorphisms (SNPs). We estimated the SNP-based heritability of levels of three liver enzymes (gamma-glutamyl transferase (GGT); alanine aminotransferase (ALT); and aspartate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.