Article
Evidence for presence of mismatch repair gene expression positive Lynch syndrome cases in India.
Molecular carcinogenesis - 1 Dec 2015
Bashyam Murali D, Kotapalli Viswakalyan, Raman Ratheesh, Chaudhary Ajay K, Yadav Brijesh K, Gowrishankar Swarnalata, Uppin Shantveer G, Kongara Ravikanth, Sastry Regulagadda A, Vamsy Mohana, Patnaik Sujit, Rao Satish, Dsouza Shoba, Desai Devendra, Tester Ashavaid
Abstract excerpt
Lynch syndrome (LS), the most common form of familial CRC predisposition that causes tumor onset at a young age, is characterized by the presence of microsatellite instability (MSI) in tumors due to germline inactivation of mismatch repair (MMR) system. Two MMR genes namely MLH1 and MSH2 account for majority of LS cases while MSH6 and PMS2 may account for a minor proportion. In order to identify MMR genes causing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.