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Dual roles for immune metagenes in breast cancer prognosis and therapy prediction

27 Oct 2014

Abstract excerpt

BACKGROUND: Neoadjuvant chemotherapy for breast cancer leads to considerable variability in clinical responses, with only 10 to 20% of cases achieving complete pathologic responses (pCR). Biological and clinical factors that determine the extent of pCR are incompletely understood. Mounting evidence indicates that the patient's immune system contributes to tumor regression and can be modulated by therapies. The...

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PMID: 25419236
DOI: 10.1186/s13073-014-0080-8

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