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Article

A thermostable transketolase evolved for aliphatic aldehyde acceptors.

Chemical communications (Cambridge, England) - 11 Jan 2015

Yi Dong, Saravanan Thangavelu, Devamani Titu, Charmantray Franck, Hecquet Laurence, Fessner Wolf-Dieter

Abstract excerpt

Directed evolution of the thermostable transketolase from Geobacillus stearothermophilus based on a pH-based colorimetric screening of smart libraries yielded several mutants with up to 16-fold higher activity for aliphatic aldehydes and high enantioselectivity (>95% ee) in the asymmetric carboligation step.

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Identifiers

PMID: 25415647
DOI: 10.1039/c4cc08436e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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