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Article

Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence.

Developmental biology - 1 May 2013

Garcia Thomas Xavier, DeFalco Tony, Capel Blanche, Hofmann Marie-Claude

Abstract excerpt

Notch signaling components have long been detected in Sertoli and germ cells in the developing and mature testis. However, the role of this pathway in testis development and spermatogenesis remains unknown. Using reporter mice expressing green fluorescent protein following Notch receptor activation, we found that Notch signaling was active in Sertoli cells at various fetal, neonatal, and adult stages. Since Notch...

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Identifiers

PMID: 23391689
DOI: 10.1016/j.ydbio.2013.01.031
PMCID: PMC3630254

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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