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Article

Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer

20 Nov 2014

Abstract excerpt

BACKGROUND: Telomeres are TTAGGG tandem repeats capping chromosomal ends and partially controlled by the telomerase enzyme. The EGFR pathway putatively regulates telomerase function, prompting an investigation of telomere length (TL) and its association with anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (mCRC). METHODS: Colorectal cancer cell lines were treated with multiple...

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Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer
Share to Telomeres, Telomerase, and Senescence

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PMID: 25412235
DOI: 10.1038/bjc.2014.561

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