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Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers

1 Apr 2010

Abstract excerpt

BACKGROUND: Telomeres, located at chromosome ends, are progressively shortened during each cell cycle by replication-dependent loss of DNA termini. Although maintenance of telomere length is critical for cell-replicative potential and tumourigenesis, the erosion of telomeres can lead to genetic instability, a pivotal mechanism in the neoplastic process. PATIENTS AND METHODS: A total of 118 colorectal cancer (CRC)...

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Share to Epigenetics and DNA Methylation
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Share to Telomeres, Telomerase, and Senescence

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PMID: 20386541
DOI: 10.1038/sj.bjc.6605644

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