Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer.

doi:10.18632/oncotarget.9015

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Article

Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer.

Oncotarget - 14 Jun 2016

Suraweera Nirosha, Mouradov Dmitri, Li Shan, Jorissen Robert N, Hampson Debbie, Ghosh Anil, Sengupta Neel, Thaha Mohamed, Ahmed Shafi, Kirwan Michael, Aleva Floor, Propper David, Feakins Roger M, Vulliamy Tom, Elwood Ngaire J, Tian Pei, Ward Robyn L, Hawkins Nicholas J, Xu Zheng-Zhou, Molloy Peter L, Jones Ian T, Croxford Matthew, Gibbs Peter, Silver Andrew, Sieber Oliver M

Abstract excerpt

Telomeric dysfunction is linked to colorectal cancer (CRC) initiation. However, the relationship of normal tissue and tumor telomere lengths with CRC progression, molecular features and prognosis is unclear. Here, we measured relative telomere length (RTL) by real-time quantitative PCR in 90 adenomas (aRTL), 419 stage I-IV CRCs (cRTL) and adjacent normal mucosa (nRTL). Age-adjusted RTL was analyzed against...

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Identifiers

PMID: 27167335
DOI: 10.18632/oncotarget.9015
PMCID: PMC5095014

Genes

BRAF
KRAS
TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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