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Article

Prevention of nocturnal elevation of intraocular pressure by gene transfer of dominant-negative RhoA in rats.

JAMA ophthalmology - 1 Feb 2015

Borrás Teresa, Buie LaKisha K, Spiga Maria-Grazia, Carabana Juan

Abstract excerpt

IMPORTANCE: We developed a gene transfer tool for the control of nocturnal elevated intraocular pressure (IOP). OBJECTIVE: To demonstrate that inhibiting the trabecular meshwork RhoA pathway by delivering a mutated, dominant-negative RhoA gene (dnRhoA) carried inside a long-expressing recombinant virus would reduce nocturnal elevated IOP in a living animal. DESIGN AND SETTING: We generated an optimized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25412195
DOI: 10.1001/jamaophthalmol.2014.4747
PMCID: PMC4527865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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