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Article

Differential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Nov 2014

Tallaksen-Greene Sara J, Sadagurski Marianna, Zeng Li, Mauch Roseanne, Perkins Matthew, Banduseela Varuna C, Lieberman Andrew P, Miller Richard A, Paulson Henry L, Albin Roger L

Abstract excerpt

The common neurodegenerative syndromes exhibit age-related incidence, and many Mendelian neurodegenerative diseases exhibit age-related penetrance. Mutations slowing aging retard age related pathologies. To assess whether delayed aging retards the effects of a mutant allele causing a Huntington's disease (HD)-like syndrome, we generated compound mutant mice, placing a dominant HD knock-in polyglutamine allele...

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Identifiers

PMID: 25411494
DOI: 10.1523/JNEUROSCI.1830-14.2014
PMCID: PMC4236397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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