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Article

OCT4 Expression Enhances Features of Cancer Stem Cells in a Mouse Model of Breast Cancer

1 Jan 2011

Abstract excerpt

The cancer stem cell (CSC) hypothesis proposes that CSCs are responsible for metastasis and disease recurrence. Therefore, targeting CSCs has the potential to significantly improve outcomes for cancer patients. The OCT4 transcription factor gene is a master gene that plays a key role in the self-renewal and pluripotency of stem cells. In this study, we introduced an OCT4 reporting vector into 4T1 mouse breast...

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Identifiers

PMID: 21826175
DOI: 10.5625/lar.2011.27.2.147

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