A high proportion of mutations in the BRCA1 gene in German breast/ovarian cancer families with clustering of mutations in the 3' third of the gene.

doi:10.1007/s004390050799

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Article

A high proportion of mutations in the BRCA1 gene in German breast/ovarian cancer families with clustering of mutations in the 3' third of the gene.

Human genetics - 1 Aug 1998

Dong J, Chang-Claude J, Wu Y, Schumacher V, Debatin I, Tonin P, Royer-Pokora B

Abstract excerpt

We have analyzed 61 German breast and breast/ovarian cancer families for BRCA1 mutations using single-strand conformation polymorphism analysis (SSCP) followed by sequencing. Forty-seven of the families had at least three cases (at least two under 60 years) and 14 families had only two cases of b...

Topics

BRCA1 Protein
Breast Neoplasms
Female
Germany
Humans
Male
Middle Aged
Multigene Family
Mutation
Ovarian Neoplasms
Pedigree
Polymorphism, Genetic

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