Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of COMT Val158Met-polymorphism on appetitive conditioning and amygdala/prefrontal effective connectivity.

Human brain mapping - 1 Mar 2015

Klucken Tim, Kruse Onno, Wehrum-Osinsky Sina, Hennig Juergen, Schweckendiek Jan, Stark Rudolf

Abstract excerpt

Appetitive conditioning is an important mechanism for the development, maintenance, and treatment of psychiatric disorders like substance abuse. Therefore, it is important to identify genetic variations, which impact appetitive conditioning. It has been suggested that the Val(158) Met-polymorphism in the Catechol-O-Methyl-Transferase (COMT) is associated with the alteration of neural processes of appetitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Arousal
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Classical

Share to Connectome

Share to Neural Pathways

Share to Prefrontal Cortex

Share to Reward

Source

Open in PubMed Open full text

Identifiers

PMID: 25394948
DOI: 10.1002/hbm.22688
PMCID: PMC6869287

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of COMT Val158Met-polymorphism on appetitive conditioning and amygdala/prefrontal effective connectivity.PMID 25394948Read ↗

The 5-HTTLPR polymorphism is associated with altered hemodynamic responses during appetitive conditioning.Semantic proximity Read ↗

Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype.Semantic proximity Read ↗

Catechol-O-methyltransferase gene variation: impact on amygdala response to aversive stimuli.Semantic proximity Read ↗

COMT genetic variation affects fear processing: psychophysiological evidence.Semantic proximity Read ↗

Gene-gene effects on central processing of aversive stimuli.Semantic proximity Read ↗

The role of the COMT val158met polymorphism in mediating aversive learning in visual cortex.Semantic proximity Read ↗

Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorderSemantic proximity Read ↗

Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder.Semantic proximity Read ↗

Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.Semantic proximity Read ↗

Multilevel impact of the dopamine system on the emotion-potentiated startle reflex.Semantic proximity Read ↗

COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.Semantic proximity Read ↗

Interaction between COMT Val(158)Met polymorphism and childhood adversity affects reward processing in adulthood.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.