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Article

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Nov 2014

Tsunemi Taiji, Hamada Kana, Krainc Dimitri

Abstract excerpt

Kufor-Rakeb syndrome (KRS) is caused by loss-of-function mutations in ATP13A2 (PARK9) and characterized by juvenile-onset parkinsonism, pyramidal signs, and cognitive decline. Previous studies suggested that PARK9 deficiency causes lysosomal dysfunction and α-synuclein (α-syn) accumulation, whereas PARK9 overexpression suppresses toxicity of α-syn. However, the precise mechanism of PARK9 effect on lysosomes and...

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Identifiers

PMID: 25392495
DOI: 10.1523/JNEUROSCI.1629-14.2014
PMCID: PMC4228131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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