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Article

The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin.

The Journal of cell biology - 9 Jun 2003

Kovar David R, Kuhn Jeffrey R, Tichy Andrea L, Pollard Thomas D

Abstract excerpt

Cytokinesis in most eukaryotes requires the assembly and contraction of a ring of actin filaments and myosin II. The fission yeast Schizosaccharomyces pombe requires the formin Cdc12p and profilin (Cdc3p) early in the assembly of the contractile ring. The proline-rich formin homology (FH) 1 domain binds profilin, and the FH2 domain binds actin. Expression of a construct consisting of the Cdc12 FH1 and FH2 domains...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12796476
DOI: 10.1083/jcb.200211078
PMCID: PMC2172974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin.PMID 12796476Read ↗

Regulation and targeting of the fission yeast formin cdc12p in cytokinesis.Semantic proximity Read ↗

Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.Semantic proximity Read ↗

Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.Semantic proximity Read ↗

The functionally distinct fission yeast formins have specific actin-assembly properties.Semantic proximity Read ↗

The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.Semantic proximity Read ↗

Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin.Semantic proximity Read ↗

The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis.Semantic proximity Read ↗

Molecular organization of cytokinesis nodes and contractile rings by super-resolution fluorescence microscopy of live fission yeast.Semantic proximity Read ↗

cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin.Semantic proximity Read ↗

Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring.Semantic proximity Read ↗

Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.Semantic proximity Read ↗

Displacement of formins from growing barbed ends by bud14 is critical for actin cable architecture and function.Semantic proximity Read ↗

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