Article
Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence in Staphylococcus aureus.
Molecular microbiology - 1 Feb 2015
Mashruwala Ameya A, Pang Yun Y, Rosario-Cruz Zuelay, Chahal Harsimranjit K, Benson Meredith A, Mike Laura A, Skaar Eric P, Torres Victor J, Nauseef William M, Boyd Jeffrey M
Abstract excerpt
The acquisition and metabolism of iron (Fe) by the human pathogen Staphylococcus aureus is critical for disease progression. S. aureus requires Fe to synthesize inorganic cofactors called iron-sulfur (Fe-S) clusters, which are required for functional Fe-S proteins. In this study we investigated the mechanisms utilized by S. aureus to metabolize Fe-S clusters. We identified that S. aureus utilizes the Suf...
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