Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.

Molecular and cellular biology - 1 Jan 2015

Eifler Tristan T, Shao Wei, Bartholomeeusen Koen, Fujinaga Koh, Jäger Stefanie, Johnson Jeff R, Luo Zeping, Krogan Nevan J, Peterlin B Matija

Abstract excerpt

Transcriptional cyclin-dependent kinases (CDKs) regulate RNA polymerase II initiation and elongation as well as cotranscriptional mRNA processing. In this report, we describe an important role for CDK12 in the epidermal growth factor (EGF)-induced c-FOS proto-oncogene expression in mammalian cells. This kinase was found in the exon junction complexes (EJC) together with SR proteins and was thus recruited to RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinases
Share to Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphorylation

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-fos

Share to RNA, Messenger

Share to RNA Polymerase II

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 25384976
DOI: 10.1128/MCB.01157-14
PMCID: PMC4272423

Genes

FOS
CDK12
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.PMID 25384976Read ↗

CDK12 is Necessary to Promote Epidermal Differentiation through Transcription ElongationSemantic proximity Read ↗

14-3-3 proteins integrate E2F activity with the DNA damage response.Semantic proximity Read ↗

An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF.Semantic proximity Read ↗

Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.Semantic proximity Read ↗

The suppressor of forked protein of Drosophila, a homologue of the human 77K protein required for mRNA 3'-end formation, accumulates in mitotically-active cells.Semantic proximity Read ↗

A unique downstream estrogen responsive unit mediates estrogen induction of proteinase inhibitor-9, a cellular inhibitor of IL-1beta- converting enzyme (caspase 1).Semantic proximity Read ↗

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like elementSemantic proximity Read ↗

Characterization of the 5'-flanking region of the mouse asparagine-linked glycosylation 12 homolog gene.Semantic proximity Read ↗

Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus.Semantic proximity Read ↗

CCAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPdelta contribute to growth hormone-regulated transcription of c-fos.Semantic proximity Read ↗

Regulation of human papillomavirus transcription by the differentiation-dependent epithelial factor Epoc-1/skn-1a.Semantic proximity Read ↗

Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.