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Development of a reverse genetics system based on RNA polymerase II for Newcastle disease virus genotype VII.

Virus genes - 1 Feb 2015

Wang Jianzhong, Wang Chunfeng, Feng Na, Wang Hualei, Zheng Xuexing, Yang Songtao, Gao Yuwei, Xia Xianzhu, Yin Renfu, Liu Xiufan, Hu Shunlin, Ding Chan, Yu Shengqing, Cong Yanlong, Ding Zhuang

Abstract excerpt

Newcastle disease virus (NDV) has only a single serotype but diversified genotypes. Genotype VII strains are the prevalent currently circulating genotype worldwide, and in particular, these strains cause outbreaks in waterfowl. In this study, a reverse genetics system for highly virulent NDV isolated from goose flocks was developed independent of conventional T7 RNA polymerase. Infectious virus was successfully...

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PMID: 25384536
DOI: 10.1007/s11262-014-1137-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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