Article
Generation and evaluation of a genetically attenuated Newcastle disease virus rGM-VIIm as a genotype-matched vaccine.
Virus genes - 1 Feb 2017
Sun Minhua, Xiang Bin, Li Yaling, Xie Peng, Gao Shimin, Kang Yinfeng, Gao Pei, Li Yanling, Wang Zhaoxiong, Liang Jianpeng, Yu Deshui, Ren Tao
Abstract excerpt
Despite intensive vaccination campaigns, outbreaks of Newcastle disease (ND) have been frequently reported in China, especially of genotype VII that first emerged in the late 1990s. Given the dire need for vaccines against the circulating genotype VII virus, we developed an alternative method to recover a highly virulent recombinant GM (rGM) virus that involves a T7 system with a hammerhead ribozyme sequence...
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