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Article

Stability of Iowa mutant and wild type Aβ-peptide aggregates.

The Journal of chemical physics - 7 Nov 2014

Alred Erik J, Scheele Emily G, Berhanu Workalemahu M, Hansmann Ulrich H E

Abstract excerpt

Recent experiments indicate a connection between the structure of amyloid aggregates and their cytotoxicity as related to neurodegenerative diseases. Of particular interest is the Iowa Mutant, which causes early-onset of Alzheimer's disease. While wild-type Amyloid β-peptides form only parallel beta-sheet aggregates, the mutant also forms meta-stable antiparallel beta sheets. Since these structural variations may...

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Identifiers

PMID: 25381547
DOI: 10.1063/1.4900892
PMCID: PMC4241800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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