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Article

Notch3 activation is sufficient but not required for inducing human T-lineage specification.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Waegemans Els, Van de Walle Inge, De Medts Jelle, De Smedt Magda, Kerre Tessa, Vandekerckhove Bart, Leclercq Georges, Wang Tao, Plum Jean, Taghon Tom

Abstract excerpt

Although the role for the individual Notch receptors in early hematopoiesis have been thoroughly investigated in mouse, studies in human have been mostly limited to the use of pan-Notch inhibitors. However, such studies in human are important to predict potential side effects of specific Notch receptor blocking reagents because these are currently being considered as therapeutic tools to treat various...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25381438
DOI: 10.4049/jimmunol.1400764

Genes

DLL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Notch3 activation is sufficient but not required for inducing human T-lineage specification.PMID 25381438Read ↗

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Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3Semantic proximity Read ↗

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Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.Semantic proximity Read ↗

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Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitorsSemantic proximity Read ↗

Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice.Semantic proximity Read ↗

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Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathwaySemantic proximity Read ↗

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