Article
The discovery of integrated gene networks for autism and related disorders.
Genome research - 1 Jan 2015
Hormozdiari Fereydoun, Penn Osnat, Borenstein Elhanan, Eichler Evan E
Abstract excerpt
Despite considerable genetic heterogeneity underlying neurodevelopmental diseases, there is compelling evidence that many disease genes will map to a much smaller number of biological subnetworks. We developed a computational method, termed MAGI (merging affected genes into integrated networks), that simultaneously integrates protein-protein interactions and RNA-seq expression profiles during brain development to...
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