Article
Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 2009
Miyagawa Shinichi, Satoh Yoshihiko, Haraguchi Ryuma, Suzuki Kentaro, Iguchi Taisen, Taketo Makoto M, Nakagata Naomi, Matsumoto Takahiro, Takeyama Ken-ichi, Kato Shigeaki, Yamada Gen
Abstract excerpt
In most mammals, the sexually dimorphic development of embryos is typically achieved by the differentiation of the external genitalia. Hence, the sexual distinction of mammalian newborns is based on the external genital structure. Although it was shown in the 1940s and 1950s that androgen from the testes establishes the male sexual characteristics, the involvement of nongonadal and locally produced masculine...
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