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Article

Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies

15 Jul 2015

Abstract excerpt

Analysis of matrix metalloproteinases (MMPs) expression profiles in various pathologies correlated with their presence in promoting disease progression. Drugs were designed to inhibit MMPs in an extreme manner by chelating the active site zinc ion. This approach did not distinguish between the 24 members of the MMP family and had devastating consequences during clinical trials. Subsequent knockout mouse studies...

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PMID: 26174966
DOI: 10.1586/14789450.2015.1069190

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