Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineering attenuated virulence of a Theileria annulata-infected macrophage.

PLoS neglected tropical diseases - 1 Jan 2014

Echebli Nadia, Mhadhbi Moez, Chaussepied Marie, Vayssettes Catherine, Di Santo James P, Darghouth Mohamed Aziz, Langsley Gordon

Abstract excerpt

Live attenuated vaccines are used to combat tropical theileriosis in North Africa, the Middle East, India, and China. The attenuation process is empirical and occurs only after many months, sometimes years, of in vitro culture of virulent clinical isolates. During this extensive culturing, attenuated lines lose their vaccine potential. To circumvent this we engineered the rapid ablation of the host cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibronectins
Share to Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-jun

Share to Protozoan Vaccines

Share to Spleen

Share to Theileriasis

Share to Vaccination

Share to Vaccines, Attenuated

Source

Open in PubMed Open full text

Identifiers

PMID: 25375322
DOI: 10.1371/journal.pntd.0003183
PMCID: PMC4222746

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Engineering attenuated virulence of a Theileria annulata-infected macrophage.PMID 25375322Read ↗

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection.Semantic proximity Read ↗

Influenza A and B viruses expressing altered NS1 proteins: A vaccine approachSemantic proximity Read ↗

A mouse attenuated mutant of Junin virus with an altered envelope glycoprotein.Semantic proximity Read ↗

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse.Semantic proximity Read ↗

Lymphatic dissemination and comparative pathology of recombinant measles viruses in genetically modified mice.Semantic proximity Read ↗

Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites.Semantic proximity Read ↗

Macrophage-parasite relationship in theileriosis. Reversible phenotypic and functional dedifferentiation of macrophages infected with Theileria annulata.Semantic proximity Read ↗

Heterogeneity and stability characteristics of Candid 1 attenuated strain of Junin virus.Semantic proximity Read ↗

Experimental infection of suckling mice with a host range mutant of Junin virus.Semantic proximity Read ↗

[Attenuation in the virulence of a mutant of Junin virus in suckling mice].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.